Human ATP-binding cassette (ABC) transporter family
نویسندگان
چکیده
منابع مشابه
The human ATP-binding cassette (ABC) transporter superfamily.
The ATP-binding cassette (ABC) transporter superfamily contains membrane proteins that translocate a variety of substrates across extra- and intra-cellular membranes. Genetic variation in these genes is the cause of or contributor to a wide variety of human disorders with Mendelian and complex inheritance, including cystic fibrosis, neurological disease, retinal degeneration, cholesterol and bi...
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In this review we reported and discussed the structural features of the ATP-Binding Cassette (ABC) transporter ABCA3 and how the use of bioinformatics tools could help researchers to obtain a reliable structural model of this important transporter. In fact, a model of ABCA3 is still lacking and no crystallographic structures (of the transporter or of its orthologues) are available. With the adv...
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Till date the largest known family of transporters is ABC transporter superfamily. The genes that encode ABC genes are widely dispersed in genome and show a high degree of amino acid sequence identity among eukaryotes. Phylogenetic analysis has allowed the gene superfamily divided into seven subfamilies containing 49 members of proteins in human. Despite the immense amount of biochemical studie...
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The ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of substrates including amino acids, lipids, inorganic ions, peptides, saccharides, metals, drugs, and proteins. The ABC transporters not only move a variety of substrates into and out of the cell, but also are also involved in intrac...
متن کاملThe role of ATP-binding cassette transporter A2 in childhood acute lymphoblastic leukemia multidrug resistance
Acute lymphoblastic leukemia (ALL) is one of the most prevalent hematologic malignancies in children. Although the cure rate of ALL has improved over the past decades, the most important reason for ALL treatment failure is multidrug resistance (MDR) phenomenon. The current study aims to explain the mechanisms involved in multidrug resistance of childhood ALL, and introduces ATP-binding cassette...
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ژورنال
عنوان ژورنال: Human Genomics
سال: 2008
ISSN: 1479-7364
DOI: 10.1186/1479-7364-3-3-281